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following adverse reactions have been associated with the use of amphetamine, ADDERALL XR, or ADDERALL:CardiovascularPalpitations. There have been isolated reports of cardiomyopathy associated with chronic amphetamine use.Central Nervous SystemPsychotic episodes at recommended doses, overstimulation, restlessness, irritability, euphoria, dyskinesia, dysphoria, depression, tremor, tics, aggression, anger, logorrhea, dermatillomania, paresthesia (including formication), and bruxism.Eye DisordersVision blurred, mydriasis.GastrointestinalUnpleasant taste, constipation, other gastrointestinal disturbances.AllergicUrticaria, rash, hypersensitivity reactions including angioedema and anaphylaxis. Serious skin rashes, including Stevens-Johnson Syndrome and toxic epidermal necrolysis have been reported.EndocrineImpotence, changes in libido, frequent or prolonged erections.SkinAlopecia.Vascular DisordersRaynaud's phenomenon.Musculoskeletal and Connective Tissue DisordersRhabdomyolysis. Limitations of the study should also be noted. First, given the nature of the pilot study, the sample size is quite small and future studies with large samples are needed to further explore the neurocognitive effects of prescription stimulants. Studies are also needed to investigate potential placebo responding on task performance, and on perceived drug effects on task performance . In addition, neurocognitive testing was conducted 90 210 min post-drug, which is the peak period of drug effects on emotion and autonomic activity. Potential drug effects on neurocognition beyond this time period were not evaluated. The study had high power to detect large effects, and lower power to detect moderate to small effects. As such the likelihood of Type II error is greater for small to medium effects. Findings with small to medium effect sizes (identified in Table 1 and Table 3 ) will require larger sample sizes in future work. Despite these limitations, the present study had adequate power for large effects and indicated dissociable effects of Adderall on neurocognition and activation, indicating differential acute impact on these outcomes. QL =
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