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What are the risks and what does the new warning advise
These medications disrupt and weaken the underlying structure of tendons perhaps by boosting levels of enzymes that damage soft-tissue cells Another theory holds that they interfere with the way your body replicates DNA a process essential to repairing minor damage running might cause Dr Miller said Combine that with the force runners place on their tendons over the miles and disaster may ensue
The average person taking these drugs has a 70 percent greater risk of tendinopathy and a 30 percent greater risk for a full-blown rupture than someone taking a different antibiotic according to a recent review article Because much of the Achilles tendon has little blood supply its more prone to injury to begin with Dr Miller said Its also the most affected by fluoroquinolones The antibiotics quadruple the risk of Achilles tendon rupture
The higher your dosage and the longer you take the medication the greater the danger Older runners people with kidney disease and those who take medications called corticosteroids (often used to manage asthma) are the most vulnerable And the risk doesn't disappear as soon as you're done with the meds Tendon problems linked to the drugs might crop up weeks months or even years later Dr Miller said
Tendon ruptures are rare to begin withoccurring only in about seven in 100000 people [4] But the consequences are so direincluding lengthy rehab and a high risk of recurrencethat physicians like Dr Jotwani already avoid prescribing fluoroquinolones to active patie (http://www.southbrookmc.com/wp/wp-content/themes/ample/product.php?name=x9i0e6-tie)nts unless theres no other choice
The new FDA warning drives home this message Athletes or not people with common infections like sinusitis bronchitis or simple urinary tract infections shouldnt take the drug unless they have no other options the agency stated In addition to tendon problems other rare but serious side effects of the drugs include nerve damage confusion and hallucinations
What should runners do
You should always weigh the benefits and risks of any medication including how it might affect your running That's one good reason to have a doctor who understands athletes and knows about your training Dr Jotwani said In general he advises active people to avoid these drugs if at all possible Ask your doctor if another antibiotic will work instead
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