Clofazimine produces pink to brownish skin pigmentation in 75-100% of patients within a few weeks, as well as similar discoloration of most bodily fluids and secretions. These discolorations are reversible but may take months to years to disappear. The prescribing information indicates that several patients have developed depression as a result of this chronic skin discoloration, resulting in two suicides. Available Dosage Forms: Side effects Orange Juice Using clofazimine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use clofazimine, or give you special instructions about the use of food, alcohol, or tobacco. Missed Dose colicky or burning abdominal or stomach pain Clofazimine is marketed under the trade name Lamprene by Novartis. One of the only suppliers of clofazimine's active pharmaceutical ingredient in the world is Sangrose Laboratories, located at Mavelikara in the southern Indian state of Kerala. clomid faux positif
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Studies on clofazimine have been done only in adult patients, and there is no specific information comparing use of clofazimine in children with use in other age groups. yellow eyes or skin—may be an orange color if already have a pink to brownish-black skin or eye discoloration If you miss a dose of clofazimine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Immunosuppressive effects Several clinical trials were also conducted looking for its immunosuppressive activity even before it was approved for leprosy by FDA. It was first reported to be effective in treating chronic discoid lupus erythematosus with 17 out of 26 patients got remission.[15] But later another group found it was ineffective in treating diffuse, photosensitive, systemic lupus erythematosus.[16] Clofazimine also has been sporadically reported with some success in other autoimmune diseases such as psoriasis,[17] Miescher’s granulomatous cheilitis,[18] Crohn’s disease and ulcerative colitis.[19] A recent clinical study of clofazimine was done in post-bone marrow transplantation patients [20] with over 50% of them having skin involvement, flexion contractures or oral manifestations achieved complete or partial responses. 7 out of 22 patients were able to reduce other immunosuppressants such as cyclosporine A.
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Studies on clofazimine have been done only in adult patients, and there is no specific information comparing use of clofazimine in children with use in other age groups. Available Dosage Forms: Clofazimine is marketed under the trade name Lamprene by Novartis. One of the only suppliers of clofazimine's active pharmaceutical ingredient in the world is Sangrose Laboratories, located at Mavelikara in the southern Indian state of Kerala. Clofazimine does also act as FIASMA (functional inhibitor of acid sphingomyelinase).[6] The presence of other medical problems may affect the use of clofazimine. Make sure you tell your doctor if you have any other medical problems, especially: Pediatric Breast Feeding
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Aluminum Hydroxide Geriatric Tell your doctor if you have ever had any unusual or allergic reaction to clofazimine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
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clofazimine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at the same time every day. If you need help in planning the best time to take your medicine, check with your health care professional. Clofazimine is taken to treat leprosy (Hansen's disease). It is sometimes given with other medicines for leprosy. When clofazimine is used to treat ``flare-ups'' of leprosy, it may be given with a cortisone-like medicine. Clofazimine may also be used for other problems as determined by your doctor. Capsule clofazimine is available only with your doctor's prescription. Clofazimine should be taken with meals or milk. Side effects 40-50% of patients develop gastrointestinal intolerance. Rarely, patients have died from bowel obstructions and intestinal bleeding, or required abdominal surgery to correct the same.
July 25 2025 03:02:45
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