Sporanox (generic name: itraconazole; brand names include: Sempera / Orungal / Itracon / Isox / Canditral / Candistat) belongs to a group of medicines called antifungal agents.
Sporanox is used for the treatment of fungal infections including blastomycosis, histoplasmosis, aspergillosis, and onychomycosis of the toenail and fingernail.
Reduced plasma concentrations of itraconazole were reported when SPORANOX® (itraconazole capsules) Capsules were administered concomitantly with H2-receptor antagonists. Studies have shown that absorption of itraconazole is impaired when gastric acid production is decreased. Therefore, SPORANOX® (itraconazole capsules) should be administered with a cola beverage if the patient has achlorhydria or is taking Hi-receptor antagonists or other gastric acid suppressors. Antacids should be administered at least 1 hour before or 2 hours after administration of SPORANOX® (itraconazole capsules) Capsules. In a clinical study, when SPORANOX® (itraconazole capsules) Capsules were administered with omeprazole (a proton pump inhibitor), the bioavailability of itraconazole was significantly reduced. Fentanyl plasma concentrations could be increased or prolonged by concomitant use of SPORANOX® (itraconazole capsules) and may cause potentially fatal respiratory depression. HMG CoA-Reductase Inhibitors The recommended dose is 200 mg once daily (2 capsules). If there is no obvious improvement, or there is evidence of progressive fungal disease, the dose should be increased in 100-mg increments to a maximum of 400 mg daily. Doses above 200 mg/day should be given in two divided doses. Antimycobacterials Aspergillosis, pulmonary and extrapulmonary, in patients who are intolerant of or who are refractory to amphotericin B therapy. Treatment of Onychomycosis See also Warning section. http://edmedics.net/frblg/achat-clomid/#clomid-when-to-take
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SPORANOX® (itraconazole capsules) Capsules is a different preparation than SPORANOX® (itraconazole capsules) Oral Solution and should not be used interchangeably. swelling, rapid weight gain; Adverse event data were derived from 602 patients treated for systemic fungal disease in U.S. clinical trials who were immunocompromised or receiving multiple concomitant medications. Treatment was discontinued in 10.5% of patients due to adverse events. The median duration before discontinuation of therapy was 81 days (range: 2 to 776 days). The table lists adverse events reported by at least 1% of patients. SPORANOX® (itraconazole capsules) may decrease the elimination of drugs metabolized by CYP3A4, resulting in increased plasma concentrations of these drugs when they are administered with SPORANOX® (itraconazole capsules) . These elevated plasma concentrations may increase or prolong both therapeutic and adverse effects of these drugs. Whenever possible, plasma concentrations of these drugs should be monitored, and dosage adjustments made after concomitant SPORANOX® (itraconazole capsules) therapy is initiated. When appropriate, clinical monitoring for signs or symptoms of increased or prolonged pharmacologic effects is advised. Upon discontinuation, depending on the dose and duration of treatment, itraconazole plasma concentrations decline gradually (especially in patients with hepatic cirrhosis or in those receiving CYP3A4 inhibitors). This is particularly important when initiating therapy with drugs whose metabolism is affected by itraconazole. SPORANOX® (itraconazole capsules) has been associated with rare cases of serious hepatotoxicity, including liver failure and death. Some of these cases had neither pre-existing liver disease nor a serious underlying medical condition. If clinical signs or symptoms develop that are consistent with liver disease, treatment should be discontinued and liver function testing performed. The risks and benefits of SPORANOX® use should be reassessed. (See WARNINGS: Hepatic Effects and PRECAUTIONS: Hepatotoxicity and PATIENT INFORMATION.)
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SPORANOX ® (itraconazole) Capsules should not be administered for the treatment of onychomycosis in patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF. If signs or symptoms of congestive heart failure occur during administration of SPORANOX® Capsules, discontinue administration. When itraconazole was administered intravenously to dogs and healthy human volunteers, negative inotropic effects were seen. (See CLINICAL PHARMACOLOGY: Special Populations, CONTRAINDICATIONS, WARNINGS, PRECAUTIONS: DRUG INTERACTIONS and ADVERSE REACTIONS: Post-marketing Experience for more information.) IV Injection: the recommended intravenous dose is 200 mg b.i.d. for four consecutive doses, followed by 200 mg once daily thereafter. Each intravenous dose should be infused over 1 hour. The safety and efficacy of SPORANOX® (itraconazole capsules) Injection administered for greater than 14 days is not known. See complete prescribing information for SPORANOX® (itraconazole) Injection. Calcium Channel Blockers feeling short of breath, even with mild exertion; Other Prior treatment with itraconazole, like other azoles, may reduce or inhibit the activity of polyenes such as amphotericin B. However, the clinical significance of this drug effect has not been clearly defined. SPORANOX® (itraconazole capsules) may inhibit the metabolism of certain glucocorticosteroids such as budesonide, dexamethasone, fluticasone and methylprednisolone.
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or Use in Patients with Hepatic Impairment In a clinical study, when 8 HIV-infected subjects were treated concomitantly with SPORANOX® (itraconazole capsules) Capsules 100 mg twice daily and the nucleoside reverse transcriptase inhibitor zidovudine 8 ± 0.4 mg/kg/day, the pharmacokinetics of zidovudine were not affected. Other nucleoside reverse transcriptase inhibitors have not been studied.
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Non-nucleoside Reverse Transcriptase Inhibitors numbness or tingly feeling; SPORANOX® (itraconazole capsules) Capsules and SPORANOX® (itraconazole capsules) Oral Solution should not be used interchangeably. Only the oral solution has been demonstrated effective for oral and/or esophageal candidiasis. Macrolide Antibiotics Antineoplasties Reduced plasma concentrations of itraconazole were reported when SPORANOX® (itraconazole capsules) Capsules were administered concomitantly with H2-receptor antagonists. Studies have shown that absorption of itraconazole is impaired when gastric acid production is decreased. Therefore, SPORANOX® (itraconazole capsules) should be administered with a cola beverage if the patient has achlorhydria or is taking Hi-receptor antagonists or other gastric acid suppressors. Antacids should be administered at least 1 hour before or 2 hours after administration of SPORANOX® (itraconazole capsules) Capsules. In a clinical study, when SPORANOX® (itraconazole capsules) Capsules were administered with omeprazole (a proton pump inhibitor), the bioavailability of itraconazole was significantly reduced. swelling, rapid weight gain;
July 23 2025 13:01:13
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