Prophylactic drug administration should begin 1 week before arrival in an endemic area. Subsequent weekly doses should be taken regularly, always on the same day of each week, preferably after the main meal. To reduce the risk of malaria after leaving an endemic area, prophylaxis must be continued for 4 additional weeks to ensure suppressive blood levels of the drug when merozoites emerge from the liver. Tablets should not be taken on an empty stomach and should be administered with at least 8 oz (240 mL) of water. to seek medical attention for any febrile illness that occurs after return from a malarious area and to inform their physician that they may have been exposed to malaria. Malaria Prophylaxis: The recommended prophylactic dose of Mefloquine hydrochloride tablets is approximately 5 mg/kg body weight once weekly. One 250 mg Mefloquine hydrochloride tablet should be taken once weekly in pediatric patients weighing over 45 kg. In pediatric patients weighing less than 45 kg, the weekly dose decreases in proportion to body weight: Mefloquine is excreted in human milk in small amounts, the activity of which is unknown. Based on a study in a few subjects, low concentrations (3% to 4%) of Mefloquine were excreted in human milk following a dose equivalent to 250 mg of the free base. Caution should be exercised when administering to a nursing woman. Cases of agranulocytosis and aplastic anemia have been reported during Mefloquine hydrochloride tablets therapy (see ADVERSE REACTIONS). No other drug interactions are known. Nevertheless, the effects of Mefloquine on travelers receiving co-medication, particularly diabetics or patients using anticoagulants, should be checked before departure. Concomitant administration of Mefloquine and quinine or chloroquine may increase the risk of convulsions. Inactive ingredients: colloidal silicon dioxide, corn starch, crospovidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, poloxamer and talc. clomid douleur ventre
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Published data on Mefloquine use during pregnancy include randomized controlled trials, intervention trials, prospective and retrospective cohort studies, and case series. These data showed that pregnant women who took Mefloquine at various doses for both prevention and treatment of malaria did not have an increased risk of teratogenic effects or adverse pregnancy outcomes compared to the background rate in the general population. These data include more than 700 exposures to Mefloquine in the first trimester of pregnancy and over 2,000 exposures in the second and third trimester. Who should not take Mefloquine? The safety and effectiveness of Mefloquine hydrochloride tablets to treat malaria in pediatric patients below the age of 6 months have not been established. severe anxiety If you take Mefloquine for a year or longer, your doctor should check your
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DOSAGE AND ADMINISTRATION Data from published studies in pregnant women have shown no increase in the risk of teratogenic effects or adverse pregnancy outcomes following Mefloquine treatment or prophylaxis during pregnancy. Reproduction studies in mice, rats and rabbits have shown teratogenic effects at doses similar to the clinical acute treatment dose in humans. Despite the animal findings, it would appear that the possibility of fetal harm is remote, if the drug is used during pregnancy. Nevertheless, because the studies in humans cannot rule out the possibility of harm, Mefloquine should be used during pregnancy only if clearly needed. At the doses used for treatment of acute malaria infections, the symptoms possibly attributable to drug administration cannot be distinguished from those symptoms usually attributable to the disease itself. Geriatric Use Rev. A 8/2011 had recent mental problems, including anxiety disorder, schizophrenia, or psychosis (losing touch with reality) Rifampin (Potent Inducer of CYP3A4)
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Experience with Mefloquine hydrochloride tablets in pediatric patients weighing less than 20 kg is limited. Concomitant administration of Mefloquine and quinine or chloroquine may increase the risk of convulsions. In patients with impaired liver function the elimination of Mefloquine may be prolonged, leading to higher plasma levels and a higher risk of adverse reactions.
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Use protective clothing, insect repellents, and bednets to protect you from being bitten by mosquitoes. Medicine alone does not always stop you from catching malaria from mosquito bites. This Medication Guide summarizes the most important information about Mefloquine. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about Mefloquine that is written for health professionals. Concomitant administration of Mefloquine and quinine or chloroquine may increase the risk of convulsions. In vitro and in vivo studies showed no hemolysis associated with glucose-6-phosphate dehydrogenase deficiency (see ANIMAL TOXICOLOGY). Note: Patients with acute P. vivax malaria, treated with Mefloquine, are at high risk of relapse because Mefloquine does not eliminate exoerythrocytic (hepatic phase) parasites. To avoid relapse after initial treatment of the acute infection with Mefloquine, patients should subsequently be treated with an 8-aminoquinoline derivative (e.g., primaquine). DOSAGE AND ADMINISTRATION mental problems
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