Sporanox (generic name: itraconazole; brand names include: Sempera / Orungal / Itracon / Isox / Canditral / Candistat) belongs to a group of medicines called antifungal agents.
Sporanox is used for the treatment of fungal infections including blastomycosis, histoplasmosis, aspergillosis, and onychomycosis of the toenail and fingernail.
Human pharmacokinetic data suggest that SPORANOX® (itraconazole capsules) inhibits the metabolism of atorvastatin, cerivastatin, lovastatin, and simvastatin, which may increase the risk of skeletal muscle toxicity, including rhabdomyolysis. Concomitant administration of SPORANOX® (itraconazole capsules) with HMG CoA-reductase inhibitors, such as lovastatin and simvastatin, is contraindicated. (See CONTRAINDICATIONS and WARNINGS.) Specimens for fungal cultures and other relevant laboratory studies (wet mount, histopathology, serology) should be obtained before therapy to isolate and identify causative organisms. Therapy may be instituted before the results of the cultures and other laboratory studies are known; however, once these results become available, antiinfective therapy should be adjusted accordingly. numbness or tingly feeling; Prior treatment with itraconazole, like other azoles, may reduce or inhibit the activity of polyenes such as amphotericin B. However, the clinical significance of this drug effect has not been clearly defined. Other SPORANOX® (itraconazole capsules) Capsules are also indicated for the treatment of the following fungal infections in non-immunocompromised patients: SPORANOX® (itraconazole capsules) may inhibit the metabolism of busulfan, docetaxel, and vinca alkaloids. The class IA antiarrhythmic disopyramide has the potential to increase the QT interval at high plasma concentrations. Caution is advised when SPORANOX® (itraconazole capsules) and disopyramide are administered concomitantly. http://edmedics.net/frblg/achat-clomid/#clomid-diarrhee
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Non-nucleoside Reverse Transcriptase Inhibitors Severe hypoglycemia has been reported in patients concomitantly receiving azole antifungal agents and oral hypoglycemic agents. Blood glucose concentrations should be carefully monitored when SPORANOX® (itraconazole capsules) and oral hypoglycemic agents are coadministered. See also Warning section. Halofantrine has the potential to prolong the QT interval at high plasma concentrations. Caution is advised when SPORANOX® (itraconazole capsules) and halofantrine are administered concomitantly. Coadministration of SPORANOX® (itraconazole capsules) with cisapride can elevate plasma cisapride concentrations which could result in serious cardiovascular events. Therefore, concomitant administration of SPORANOX (itraconazole capsules) ® with cisapride is contraindicated. (See BOX WARNING, CONTRAINDICATIONS, and WARNINGS.)
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Prior treatment with itraconazole, like other azoles, may reduce or inhibit the activity of polyenes such as amphotericin B. However, the clinical significance of this drug effect has not been clearly defined. pain or burning when you urinate; Concomitant administration of SPORANOX® (itraconazole capsules) and alprazolam, diazepam, oral midazolam, or triazolam could lead to increased plasma concentrations of these benzodiazepines. Increased plasma concentrations could potentiate and prolong hypnotic and sedative effects. Concomitant administration of SPORANOX® (itraconazole capsules) and oral midazolam or triazolam is contraindicated. (See CONTRAINDICATIONS and WARNINGS.) If midazolam is administered parenterally, special precaution and patient monitoring is required since the sedative effect may be prolonged. Human pharmacokinetic data suggest that SPORANOX® (itraconazole capsules) inhibits the metabolism of atorvastatin, cerivastatin, lovastatin, and simvastatin, which may increase the risk of skeletal muscle toxicity, including rhabdomyolysis. Concomitant administration of SPORANOX® (itraconazole capsules) with HMG CoA-reductase inhibitors, such as lovastatin and simvastatin, is contraindicated. (See CONTRAINDICATIONS and WARNINGS.) Gastrointestinal Motility Agents SPORANOX® (itraconazole) Capsules are indicated for the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: Antiarrhythmics
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Levacetylmethadol (levomethadyl) is known to prolong the QT interval and is metabolized by CYP3A4. Co-administration of levacetylmethadol with SPORANOX® (itraconazole capsules) could result in serious cardiovascular events. Therefore, concomitant administration of SPORANOX® (itraconazole capsules) and levacetylmethadol is contraindicated. Prior to initiating treatment, appropriate nail specimens for laboratory testing (KOH preparation, fungal culture, or nail biopsy) should be obtained to confirm the diagnosis of Onychomycosis. Adverse Events in the Treatment of Systemic Fungal Infections
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Polyenes Calcium channel blockers can have a negative inotropic effect which may be additive to those of itraconazole; itraconazole can inhibit the metabolism of calcium channel blockers such as dihydropyridines (e.g., nifedipine and felodipine) and verapamil. Therefore, caution should be used when co-administering itraconazole and calcium channel blockers due to an increased risk of CHF. Concomitant administration of SPORANOX® (itraconazole capsules) and nisoldipine results in clinically significant increases in nisoldipine plasma concentrations, which cannot be managed by dosage reduction, therefore the concomitant administration of SPORANOX (itraconazole capsules) ® and nisoldipine is contraindicated. (See CLINICAL PHARMACOLOGY: Special Populations, CONTRAINDICATIONS, WARNINGS, and ADVERSE REACTIONS: Post-marketing Experience for more information). HOW SUPPLIED Concomitant administration of SPORANOX® (itraconazole capsules) and alprazolam, diazepam, oral midazolam, or triazolam could lead to increased plasma concentrations of these benzodiazepines. Increased plasma concentrations could potentiate and prolong hypnotic and sedative effects. Concomitant administration of SPORANOX® (itraconazole capsules) and oral midazolam or triazolam is contraindicated. (See CONTRAINDICATIONS and WARNINGS.) If midazolam is administered parenterally, special precaution and patient monitoring is required since the sedative effect may be prolonged. Concomitant administration of SPORANOX® (itraconazole capsules) and cyclosporine or tacrolimus has led to increased plasma concentrations of these immunosuppressants. Concomitant administration of SPORANOX® (itraconazole capsules) and sirolimus could increase plasma concentrations of sirolimus. Benzodiazepines SPORANOX® (itraconazole) Capsules are available containing 100 mg of itraconazole, with a blue opaque cap and pink transparent body, imprinted with "JANSSEN" and "SPORANOX (itraconazole capsules) 100." The capsules are supplied in unit-dose blister packs of 3 x 10 capsules (NDC 50458-290-01), bottles of 30 capsules (NDC 50458-290-04) and in the PulsePak® containing 7 blister packs x 4 capsules each (NDC 50458-290-28).
July 25 2025 10:17:00
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