Amikacin (brand names include: Amikacine / Amikin / Amicin / Amikozit / Biklin / Likacin / Miacin / Selemycin) belongs to a class of drugs known as aminoglycoside antibiotics.
Amikacin sulfate injection is indicated in the short-term treatment of serious infections.
Indications include:
bacterial septicemia (including neonatal sepsis);
serious infections of the respiratory tract, bones and joints, central nervous system (including meningitis) and skin and soft tissue;
intra-abdominal infections (including peritonitis);
burns and post operative infections (including post vascular surgery);
serious complicated and recurrent urinary tract infections.
Contraindications Normosol® M in 5% dextrose injection Amikacin Dosage and Administration Teratogenic Effects 5 References Aminoglycosides are potentially nephrotoxic. The risk of nephrotoxicity is greater in patients with impaired renal function and in those who receive high doses or prolonged therapy. Other Overdosage clomid j3
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When renal function is impaired and it is desirable to administer Amikacin at a fixed time interval, dosage must be reduced. In these patients, serum Amikacin concentrations should be measured to assure accurate administration of Amikacin and to avoid concentrations above 35 mcg/mL. If serum assay determinations are not available and the patient's condition is stable, serum creatinine and creatinine clearance values are the most readily available indicators of the degree of renal impairment to use as a guide for dosage. In certain severe infections such as neonatal sepsis, concomitant therapy with a penicillin-type drug may be indicated because of the possibility of infections due to Gram-positive organisms such as streptococci or pneumococci. Following administration at the recommended dose, therapeutic levels are found in bone, heart, gallbladder, and lung tissue in addition to significant concentrations in urine, bile, sputum, bronchial secretions, interstitial, pleural, and synovial fluids. 132 60 450 mg 300 mg (or Plasma-Lyte 148 injection in 5% dextrose in water).
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First, initiate therapy by administering a normal dose, 7.5 mg/kg, as a loading dose. This loading dose is the same as the normally recommended dose which would be calculated for a patient with a normal renal function as described above. Concurrent and/or sequential systemic, oral or topical use of other neurotoxic or nephrotoxic products, particularly bacitracin, cisplatin, amphotericin B, cephaloridine, paromomycin, viomycin, polymyxin B, colistin, vancomycin or other aminoglycosides should be avoided. Other factors that may increase risk of toxicity are advanced age and dehydration. 1 Medical uses 4 Resistance Amikacin is most often used for treating severe, hospital-acquired infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. Serratia marcescens and Providencia stuartii are also included in the spectrum. Amikacin can also be used to treat non tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first line drugs fail to control the infection. Normosol® M in 5% dextrose injection Resistance
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Tolerance studies in normal volunteers reveal that Amikacin is well tolerated locally following repeated intramuscular dosing, and when given at maximally recommended doses, no ototoxicity or nephrotoxicity has been reported. There is no evidence of drug accumulation with repeated dosing for 10 days when administered according to recommended doses. When Amikacin is indicated in newborns (see WARNINGS box), it is recommended that a loading dose of 10 mg/kg be administered initially to be followed with 7.5 mg/kg every 12 hours. Amikacin resists degradation by most aminoglycoside inactivating enzymes known to affect gentamicin, tobramycin and kanamycin.
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The recommended dosage for adults, children and older infants (see WARNINGS box) with normal renal function is 15 mg/kg/day divided into 2 or 3 equal doses administered at equally divided intervals, i.e., 7.5 mg/kg q12h or 5 mg/kg q8h. Treatment of patients in the heavier weight classes should not exceed 1.5 g/day. Aminoglycosides can cause fetal harm when administered to a pregnant woman. Aminoglycosides cross the placenta and there have been several reports of total irreversible, bilateral congenital deafness in children whose mothers received streptomycin during pregnancy. Although serious side effects to the fetus or newborns have not been reported in the treatment of pregnant women with other aminoglycosides, the potential for harm exists. Reproduction studies of Amikacin have been performed in rats and mice and revealed no evidence of impaired fertility or harm to the fetus due to Amikacin. There are no well-controlled studies in pregnant women, but investigational experience does not include any positive evidence of adverse effects to the fetus. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Whenever possible, serum Amikacin concentrations should be monitored by appropriate assay procedures. Doses may be adjusted in patients with impaired renal function either by administering normal doses at prolonged intervals or by administering reduced doses at a fixed interval. Bauer, A.W., Kirby, W.M.M., Sherris, J.C., and Turck, M.: Anitbiotic Testing by a Standardized Single Disc Method, Am. J. Clin. Pathol., 45:493, 1966; Standardized Disc Susceptibility Test, FEDERAL REGISTER, 37:2057–29, 1972. The status of renal function should be estimated by measurement of the serum creatinine concentration or calculation of the endogenous creatinine clearance rate. The blood urea nitrogen (BUN) is much less reliable for this purpose. Reassessment of renal function should be made periodically during therapy. The above dosage schedules are not intended to be rigid recommendations but are provided as guides to dosage when the measurement of Amikacin serum levels is not feasible. q12h q8h
July 23 2025 02:58:50
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