Írta: jefanaenly - Dátum: 30-11-2012 09:08
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Minocycline (generic name: minocycline hydrochloride; brand names include: Minocin / Dynacin / Myrac / Solodyn / Minomycin / Cynomycin) belongs to a group of medicines known as tetracycline antibiotics.
Minocycline is used for the treatment of various bacterial infection; for the treatment of anthrax; moderate-to-severe acne; meningococcal (asymptomatic) carrier state; Rickettsial diseases (including Rocky Mountain spotted fever, Q fever); nongonococcal urethritis, gonorrhea; and acute intestinal amebiasis.
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Mycobacterium marinum: 100 mg orally or IV every 12 hours for at least 3 months Hepatic Nervous system side effects have included convulsions, headache, hypesthesia, paresthesia, sedation, vestibular reactions including dizziness and vertigo. Decreased hearing, tinnitus, benign intracranial hypertension (pseudotumor cerebri) in adults, and bulging fontanels in infants have been reported. mild nausea, mild diarrhea, upset stomach; Other reports of immunologically-mediated progressive liver dysfunction have rarely occurred. In one case, a patient received a liver transplant following fulminant hepatic failure which was thought to be related to a 3 year history of daily minocycline therapy to treat acne. The dose of minocycline ranged from 50 mg to 200 mg per day. A second patient had been receiving minocycline therapy to treat acne for 1 year just prior to seeking medical attention for a "flu-like" syndrome. Upon hospitalization, it was determined that the patient was experiencing an autoimmune-mediated hepatitis, most probably related to minocycline. Resolution of symptoms occurred in both of these cases after minocycline therapy was discontinued and each patient had received appropriate supportive medical care. What happens if I overdose? methotrexate (Rheumatrex, Trexall); Avoid exposure to sunlight or tanning beds. Minocycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
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Usual Adult Minocycline Dose for Bacterial Infection: Dermatologic Clinical response should be monitored by CT or MRI. Take minocycline for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Minocycline will not treat a viral infection such as the common cold or flu. Other side effects associated with tetracyclines have included fatigue, malaise, somnolence, fever, and discoloration of secretions.
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Other reports of immunologically-mediated progressive liver dysfunction have rarely occurred. In one case, a patient received a liver transplant following fulminant hepatic failure which was thought to be related to a 3 year history of daily minocycline therapy to treat acne. The dose of minocycline ranged from 50 mg to 200 mg per day. A second patient had been receiving minocycline therapy to treat acne for 1 year just prior to seeking medical attention for a "flu-like" syndrome. Upon hospitalization, it was determined that the patient was experiencing an autoimmune-mediated hepatitis, most probably related to minocycline. Resolution of symptoms occurred in both of these cases after minocycline therapy was discontinued and each patient had received appropriate supportive medical care. Endocrine system side effects have included a condition characterized by dark pigmentation (brown-black microscopic discoloration) of the thyroid gland. However, there was no clinical or laboratory evidence of thyroid dysfunction. The clinical implications of this pigmentation are unknown. Abnormal thyroid function has been reported. Gastrointestinal side effects have included abdominal cramping, anorexia, diarrhea, dyspepsia, dysphagia, enamel hypoplasia, enterocolitis, esophagitis, esophageal ulcerations, glossitis, nausea, oral cavity and tooth discoloration, inflammatory lesions (with monilial overgrowth) in the oral and anogenital regions, pancreatitis, pseudomembranous colitis, stomatitis, vomiting, and dry mouth. This list is not complete and other drugs may interact with minocycline. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. if you are also using a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen). Maintenance dose: 50 to 100 mg orally once a day Hypersensitivity side effects have included anaphylactoid purpura, anaphylaxis/anaphylactoid reaction (including shock and fatalities), angioneurotic edema, autoimmune vasculitis, drug fever, eosinophilic pneumonitis, erythema multiforme, fixed drug eruptions, hepatitis, lupus-like syndrome, myocarditis, pericarditis, polyarthralgia, pulmonary infiltrates with eosinophilia, rhabdomyolysis, serum sickness, serum sickness-like reactions, Stevens-Johnson syndrome, urticaria, and severe central nervous system-pulmonary hypersensitivity syndrome. Drug rash with eosinophilia and systemic symptoms (DRESS) including fatal cases have been reported. DRESS syndrome with persistent myocarditis has been reported in at least 3 cases. Hypersensitivity syndrome (consisting of cutaneous reaction such as rash or exfoliative dermatitis, eosinophilia, and one or more of the following: hepatitis, pneumonitis, nephritis, myocarditis, and pericarditis) has been reported. Fever and lymphadenopathy may be present with hypersensitivity syndrome. Death has been reported in some cases involving hypersensitivity syndrome.
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Minocycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using minocycline. mild skin rash or itching; 45 to 49 kg: 45 mg orally once a day
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dizziness, tired feeling, spinning sensation; an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), meloxicam (Mobic), and others. Usual Adult Minocycline Dose for Skin and Structure Infection: This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Usual Adult Minocycline Dose for Meningitis -- Meningococcal: Psychiatric Minocycline passes into breast milk and may affect bone and tooth development in a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby. Children should not take this medication. Minocycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old.