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Clofazimine (brand names include: Lamprene / Hanserpan) is used in the treatment of leprosy.

Clofazimine is usually used in combination with other drugs.





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Bloody or black, tarry stools Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The presence of other medical problems may affect the use of clofazimine. Make sure you tell your doctor if you have any other medical problems, especially: Available Dosage Forms: The immunosuppressive effects of clofazimine were immediately noticed when applied in animal model. Macrophages were first reported to be inhibited due to the stabilization of lysosomal membrane by clofazimine.[8] Clofazimine also showed a dosage-dependent inhibition of neutrophil motility, lymphocyte transformation,[9] mitogen-induced PBMC proliferation [10] and complement-mediated solubilization of pre-formed immune complexes in vitro.[11] A mechanistic studying of clofazimine in human T cells revealed that this drug is a Kv1.3 (KCNA3) channel blocker.[12] This indicates that clofazimine will be potentially used for treatment of multiple sclerosis, rheumatoid arthritis and type 1 diabetes. Because the Kv1.3-high effector memory T cells (TEM) are actively involved in the development of these diseases,[13] and Kv1.3 activity is essential for stimulation and proliferation of TEM by regulating calcium influx in the T cells.[14] 40-50% of patients develop gastrointestinal intolerance. Rarely, patients have died from bowel obstructions and intestinal bleeding, or required abdominal surgery to correct the same. Wear protective clothing, including a hat. Also, wear sunglasses. clomid follicule
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If you have a severe reaction, check with your doctor . [edit] [edit] Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of clofazimine in the elderly with use in other age groups. Studies on clofazimine have been done only in adult patients, and there is no specific information comparing use of clofazimine in children with use in other age groups.
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Clofazimine may cause your skin to become more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking clofazimine: Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible. [edit] [edit] Phenytoin Less common or rare kloe-FAZ-i-meen
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Clofazimine commonly causes discoloration of the feces, lining of the eyelids, sputum, sweat, tears, and urine. Usually this side effect does not require medical attention, but the discoloration may not go away. However, clofazimine may also cause bloody or black, tarry stools. This side effect may be a symptom of serious bleeding problems that do require medical attention. Studies on clofazimine have been done only in adult patients, and there is no specific information comparing use of clofazimine in children with use in other age groups. clofazimine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at the same time every day. If you need help in planning the best time to take your medicine, check with your health care professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Do not use a sunlamp or tanning bed or booth. Mechanism colicky or burning abdominal or stomach pain