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Amikacin (brand names include: Amikacine / Amikin / Amicin / Amikozit / Biklin / Likacin / Miacin / Selemycin) belongs to a class of drugs known as aminoglycoside antibiotics.

Amikacin sulfate injection is indicated in the short-term treatment of serious infections.

Indications include:

bacterial septicemia (including neonatal sepsis);
serious infections of the respiratory tract, bones and joints, central nervous system (including meningitis) and skin and soft tissue;
intra-abdominal infections (including peritonitis);
burns and post operative infections (including post vascular surgery);
serious complicated and recurrent urinary tract infections.





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At the same concentrations, solutions frozen and aged for 30 days at -15°C, thawed, and stored at 25°C had utility times of 24 hours. With normal renal function, about 91.9% of an intramuscular dose is excreted unchanged in the urine in the first 8 hours and 98.2% within 24 hours. Mean urine concentrations for 6 hours are 563 mcg/mL following a 250 mg dose, 697 mcg/mL following a 375 mg dose and 832 mcg/mL following a 500 mg dose. If signs of renal irritation appear (casts, white or red cells or albumin), hydration should be increased. A reduction in dosage (see DOSAGE AND ADMINISTRATION) may be desirable if other evidence of renal dysfunction occurs such as decreased creatinine clearance; decreased urine specific gravity; increased BUN, creatinine or oliguria. If azotemia increases or if a progressive decrease in urinary output occurs, treatment should be stopped. Intramuscular Administration 0703-9040-03 1 gram per 4 mL Tolerance studies in normal volunteers reveal that Amikacin is well tolerated locally following repeated intramuscular dosing, and when given at maximally recommended doses, no ototoxicity or nephrotoxicity has been reported. There is no evidence of drug accumulation with repeated dosing for 10 days when administered according to recommended doses. Amikacin resists degradation by most aminoglycoside inactivating enzymes known to affect gentamicin, tobramycin and kanamycin. 1 http://edmedics.net/frblg/achat-clomid/#clomid-50-mg-effet-secondaire
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Since Amikacin is present in high concentrations in the renal excretory system, patients should be well-hydrated to minimize chemical irritation of the renal tubules. Kidney function should be assessed by the usual methods prior to starting therapy and daily during the course of treatment. Acute muscular paralysis and apnea can occur following treatment with aminoglycoside drugs. 0703-9040-03 1 gram per 4 mL Amikacin Dosage and Administration Spinal fluid levels in normal infants are approximately 10 to 20% of the serum concentrations and may reach 50% when the meninges are inflamed. Amikacin has been demonstrated to cross the placental barrier and yield significant concentrations in amniotic fluid. The peak fetal serum concentration is about 16% of the peak maternal serum concentration and maternal and fetal serum half-life values are about 2 and 3.7 hours, respectively.
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In certain severe infections such as neonatal sepsis, concomitant therapy with a penicillin-type drug may be indicated because of the possibility of infections due to Gram-positive organisms such as streptococci or pneumococci. Free Same Day Priority Air Shipping Largest Selection Of Breathalyzers Amikacin is most often used for treating severe, hospital-acquired infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. Serratia marcescens and Providencia stuartii are also included in the spectrum. Amikacin can also be used to treat non tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first line drugs fail to control the infection. Resistance Gram-negative The individual dose, the total daily dose and the total cumulative dose of Amikacin sulfate are identical to the dose recommended for intramuscular administration. The solution for intravenous use is prepared by adding the contents of a 500 mg vial to 100– 200 mL of sterile diluent such as 0.9% sodium chloride injection or 5% dextrose injection or any other compatible solution. 1 Medical uses
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NormosolÂŽ R in 5% dextrose injection Note: When patients are well hydrated and kidney function is normal, the risk of nephrotoxic reactions with Amikacin is low if the dosage recommendations (see DOSAGE AND ADMINISTRATION) are not exceeded. When renal function is impaired and it is desirable to administer Amikacin at a fixed time interval, dosage must be reduced. In these patients, serum Amikacin concentrations should be measured to assure accurate administration of Amikacin and to avoid concentrations above 35 mcg/mL. If serum assay determinations are not available and the patient's condition is stable, serum creatinine and creatinine clearance values are the most readily available indicators of the degree of renal impairment to use as a guide for dosage.

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2 Adverse effects Bacteriologic studies should be performed to identify causative organisms and their susceptibilities to Amikacin. Amikacin may be considered as initial therapy in suspected Gram-negative infections, and therapy may be instituted before obtaining the results of susceptibility testing. Clinical trials demonstrated that Amikacin was effective in infections caused by gentamicin-and/or tobramycin-resistant strains of Gram-negative organisms, particularly Proteus rettgeri, Providencia stuartii, Serratia marcescens and Pseudomonas aeruginosa. The decision to continue therapy with the drug should be based on results of the susceptibility tests, the severity of the infection, the response of the patient and the important additional considerations contained in the WARNINGS box above. Breathalyzer Megastore 209 95 712.5 mg 475 mg 4 Resistance Quantitative methods that require measurement of zone diameters give the most precise estimates of antibiotic susceptibility. One such procedure1 has been recommended for use with discs to test susceptibility to Amikacin. Interpretation involves correlation of the diameters obtained in the disc test with MIC values for Amikacin. When the causative organism is tested by the Kirby-Bauer* method of disc susceptibility, a 30 mcg Amikacin disc should give a zone of 17 mm or greater to indicate susceptibility. Zone sizes of 14 mm or less indicate resistance. Zone sizes of 15 to 16 mm indicate intermediate susceptibility. With this procedure, a report from the laboratory of "susceptible" indicates that the infecting organism is likely to respond to therapy. A report of "resistant" indicates that the infecting organism is not likely to respond to therapy. A report of "intermediate susceptibility" suggests that the organism would be susceptible if the infection is confined to tissues and fluids (e.g., urine) in which high antibiotic levels are attained. The recommended dosage for adults, children and older infants (see WARNINGS box) with normal renal function is 15 mg/kg/day divided into 2 or 3 equal doses administered at equally divided intervals, i.e., 7.5 mg/kg q12h or 5 mg/kg q8h. Treatment of patients in the heavier weight classes should not exceed 1.5 g/day.