metabolite in clinical trials of people with depression.
A potential concern is that because of ketamine’s ability to warp perceptions, it is sometimes used as a recreational drug of abuse. But the metabolite may not have the same allure. Mice will push a lever to self-administer ketamine, but don’t seem as eager to up their dose of (2R,6R)-HNK,
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, the team found. ?
More experiments are needed to show specifically how (2R,6R)-HNK affects the brain. One of the main explanations for how ketamine itself works is that it blocks NMDA receptors,
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, proteins that sit on particular nerve cells and help strengthen neural connections. But (2R,
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,6R)-HNK has nothing to do with NMDA receptors. If the new results are right, they suggest that NMDA receptors aren’t a good target for an antidepressant drug. “We thought it was one thing but now it seems like it’s something else,
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,” Malinow says.?

Smartphone-toting pilgrims regularly stream into northern Cambodia from all over the world. Their destination: Angkor Wat,
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, a medieval temple that’s famous for massive towers and majestic stone carvings of Hindu gods,
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, spirits and mythological battle scenes. The site,
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, considered the world’s largest religious monument, drew more than 2.3 million visitors in 2014.
Angkor Wat’s sightseers encounter a study in contrasts. This architectural wonder of human civilization ascends skyward,
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, on the verge of being engulfed by nature below. Tourists walk along a path

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