and major diseases,
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.
Aging as disease
Many health problems are so commonly associated with aging that some researchers take the highly controversial stance that aging itself is a disease, says Saul Villeda of the University of California,
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, San Francisco.
If aging is a disease,
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, in Villeda’s lab it’s almost a contagious one: He can artificially spread aging from old lab mice to young ones. One mode of aging transmission is to give genetically identical mice transfusions of young or old blood. In another approach,
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, researchers sew together pairs of mice so that their blood vessels will join up and link their circulatory systems.
This artificial joining of two separate animals, known as parabiosis,
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, was a staple of physiology experiments for over a century before Irina Conboy got the idea to pair an old mouse with a young one. Conboy,
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, a stem cell researcher at the University of California,
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, Berkeley, made headlines with her experiments.
Story continues below graphs

Odd couples


Scientists sewed together mice so that the rodents shared blood supplies. Young mice paired with old mice (left chart,
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, two-toned) made fewer new cells in the brain’s hippocampus than when paired with another young mouse (yellow). Old mice made hundreds more new brain cells when paired with a young mouse (right chart, two-toned) than when paired with an old mouse (teal).?


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