to move or to withstand heat or oxidative stress, found that long-lived mutant worms spend a smaller proportion of their lives as healthy animals (indicated in yellow).



Source: A,
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. Bansal et al/PNAS 2015


That lockdown is for the greater good, says aging researcher Judith Campisi,
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, who studies senescence at the Buck Institute for Research on Aging in Novato,
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, Calif. “It’s protective,” she says. “You don’t want defective cells to propagate.” (When damaged cells continue to grow they may become cancerous.)
Unfortunately,
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, says Campisi,
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, the senescent cells don’t die. Instead they send out messages to neighboring cells: “Hey, there’s a problem. Be prepared. What happened to me could happen to you.” Such messages are probably intended as public service announcements, but they could trigger mass panic and inflammation. Like zombies putting the bite on the living,
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, senescent cells damage surrounding cells and accelerate aging.
Researchers have worked out methods for hitting the zombie cells with genetic shots to the head,
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, effectively destroying the cells and removing them from the body. Mice from which senescent cells have been removed had increased median life span and improved health, researchers reported in Nature in February (SN: 3/5/16, p. ,
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.
Campisi and other researchers are working on ways to clear senescent

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