Though there was no smoking gun — no single piece of evidence that clinched Zika as the culprit — little clues began adding up,
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, beginning with the conspicuous timing of Brazil’s microcephaly upsurge (SN: 4/2/16, p. 26). In January the CDC first issued a warning to pregnant women to postpone travel to Zika-affected regions. On April 13,
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, a day that may be forever etched into Rasmussen’s memory,
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, she and colleagues reported “a causal relationship...een Zika and microcephaly, along with other birth defects,
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, in a study published online in the New England Journal of Medicine. Since then,
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, Rasmussen says, “The data have become absolutely overwhelming.”



This is the year that people became convinced that this mosquito-borne virus could cause birth defects.


— Sonja Rasmussen

In May, a mouse study offered the first direct proof in animals that in utero Zika infection can lead to microcephaly (SN Online: 5/11/16). In September, researchers reported that a pregnant pigtailed macaque infected with Zika in the third trimester then gave birth to a baby whose brain had stopped growing. In human babies, the range of disorders linked to Zika has ballooned to include problems with the eyes,
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, ears and joints, as well as seizures and extreme irritability (SN: 10/29/16, p. 14),
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. At a workshop in North Bethesda, Md., this fall, a room crowded with doctors and scientists watched videos of inconsolable infants jerking erratically, arms and legs unnaturally stiff. “Heartbreaking,
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,” Rasmussen says.

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