Some people age at different rates than others, he discovered. For instance,
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, semi-supercentenarians — people who live to be 105 to 109 — are about 8.6 years younger epigenetically than their chronological age. Their children are slow to age, too, though not as slow as their parents. Epigenetic clocks indicate that the offspring are about five years younger biologically than other people of the same chronological age.
People often joke about certain abilities,
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, such as eyesight, memory or hearing being “the first to go.” Some of Horvath’s work suggests that the notion isn’t entirely far-fetched. He calculated the epigenetic age of specific organs and discovered that body parts can age at different rates. The cerebellum,
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, the part of the brain that sits at the top of the brain stem and helps coordinate movement,
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, speech and other activities,
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, ages the slowest of the brain regions that Horvath analyzed. While there are natural differences in organ aging,
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, some conditions, such as HIV infection and obesity, can prematurely age certain organs,
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, Horvath and colleagues have found.
These experiments demonstrate that aging and its effects are malleable. “Aging is really plastic — it’s not set in stone,” says Conboy. Consequently,
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, she and other researchers agree, something can be done to slow aging, or perhaps turn it around entirely. But exactly what can be done is vigorously disputed.

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