Ways to be wellderly
A similar paradox is also seen in “wellderly” people that geneticist Ali Torkamani has been studying at the Scripps Research Institute in La Jolla,
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, Calif. About eight years ago,
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, Torkamani started bringing in people over 80 who had made it to an advanced age without any sign of chronic disease. The idea was to study their DNA and learn the secrets of healthy aging.
Despite living healthy, the wellderly didn’t carry genetic variants connected with extremely long lives,
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, Torkamani and colleagues discovered. The wellderly also had no genetic advantage when it comes to cancer,
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, stroke or diabetes. What they did have was a lower risk of getting Alzheimer’s and heart disease. Each of the wellderly seemed to have their own genetic recipe for success, suggesting
there are lots of ways...stay healthy into old age. The researchers didn’t rule out that diet and lifestyle also help. “There’s hope for everybody,
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,” Torkamani declares.
But his cloud of optimism may have a tarnished lining. His findings, along with the sea urchin and worm results, suggest that aging and longevity aren’t the same things. If that’s the case,
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, it would mean that stopping aging would not extend human life span by much. The oldest (verified) person to have ever lived was Jeanne Louise Calment,
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, a French woman who died at age 122 in 1997. People might top out at 130 if aging is controlled (and most people still would not make it that long because they just don’t have the necessary makeup). As a species,
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, humans probably can’t go further without changing whatever controls longevity too, some researchers think.
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