whole country may grind to a halt for a few weeks,
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,” says Tom Solomon,
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, a neurologist at England’s University of Liverpool who has studied enterovirus 71 in Malaysia. “Vaccination is a major step forward,” he says.
The two experimental vaccines tested use slightly different inactivated forms of enterovirus 71. Both trigger the immune system to build an army of antibodies against the real pathogen,
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.
In one trial,
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, 12,000 children between 6 months and 6 years of age received either two shots of the vaccine four weeks apart or two placebo shots. The vaccine was highly effective. While 151 children who got the placebo shots developed illness caused by enterovirus 71 over the next 11 months,
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, only four in the vaccinated group came down with it. The follow-up spanned two peak epidemic seasons in China.
In the other study, 10,007 children who were 6 months to 3 years old similarly received placebo or vaccination shots. Over a year, that vaccine also showed strong protection: 106 of the children who got the placebo,
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, but only 13 of the vaccinated kids, developed disease from enterovirus 71.
The second research team also tracked severe illness and found that 24 children in the placebo group ended up in the hospital while none of the vaccinated children did.
“Our study indicates that infants and young children can be protected against enterovirus 71–associated hand, foot and mouth disease,
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,” says Nan Wang, a coauthor of the study of 10,007 children. She is a vaccine researcher and vice president at Sinovac Biotech in Beijing,
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, which makes the vaccine

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more than 28,
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,000 people of European descent to determine whether genes from extinct ancestors were associated with diseases. Genetic variants inherited from Neandertals were associated with a slightly increased ris...pression and heart attack?as well as corns and callouses and other skin disorders, the researchers reported February 11 at the American Association for the Advancement of Science’s annual meeting in Washington, D.C.,
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, and in the Feb. 12 Science.
For instance,
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, Neandertal variants account for about 1 percent of the genetic risk of getting depression. Interestingly, some bits of Neandertal DNA actually seem to protect against depression,
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, study coauthor Corinne Simonti,
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, also of Vanderbilt University,
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, said at a press briefing at the AAAS meeting. So whether a person is depressed may depend, in part, on which bits of Neandertal DNA they inherited.
Other researchers caution that Capra’s group hasn’t demonstrated that the Neandertal variants are the genetic changes responsible for the disease. They may be innocent bystanders implicated just by their proximity to variants that are really causing problems. And,
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, says evolutionary geneticist Rasmus Nielsen of the University of California, Berkeley,
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, “because we’re talking about genetic variation here, the effect is not in one direction — so the study doesn’t show that you’re more (or less) likely to become ill because of Neandertal DNA.”
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