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Inheriting immunity



Present-day people participating in the 1000 Genomes project inherited one of three versions,
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, or haplotypes,
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, of immunity genes. Neandertals passed haplotype III to all non-Africans,
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, and some Asians also inherited Neandertal haplotype IV. Those versions of the immunity genes may have helped human ancestors fend off new pathogens, but now contribute to allergies.
Neandertal variants don’t usually fall within genes,
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, instead affecting DNA that influences where, when and how strongly genes are activated, Capra said. The Neandertal variants most strongly associated with depression were located near circadian clock genes,
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, which synchronize the body’s rhythms with the sun,
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, the researchers found. Other Neandertal variants affect activity of genes involved in bladder pain and incontinence and a gene that predisposes people to nicotine addiction. Knowing which parts of a person’s genome were inherited from Neandertals might help doctors better predict patients’ risk of disease, Capra says.
If Neandertal DNA is harmful,
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, why is it still hanging around? It may not always have been a deficit,
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, says Capra. His group found that Neandertal DNA is associated with a disorder in which the

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