weed out the slightly bad variants,
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, a group of researchers from the University of California,
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, Davis reports in a November 21 paper. Both groups agree that the burden of extra Neandertal mutations would have been a drag on early human-Neandertal hybrids. Europeans and Asians are still shouldering that mutational load today. Non-Africans are about 0.5 percent less evolutionarily fit than their African counterparts thanks to Neandertal DNA,
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, Harris and Nielsen say.
On the whole, the researchers argue,
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, Neandertals’ extremely narrow population bottleneck was bad for them and their modern human descendants. But a wealth of genetic data indicate that at least some genes inherited from humans’ extinct cousins were evolutionary windfalls. For instance,
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, a gene Tibetans inherited from Denisovans allowed them to adapt to high altitudes (SN: 8/9/14, p. 8).
Some of the most Neandertal-rich regions of the modern human genome are those that contain immune system genes. There’s a good reason for that. “Of all the challenges, forces and threats humans have faced over the course of evolution,
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, pathogens have been one of the greatest,
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,” says Lluis Quintana-Murci, a population geneticist at the Pasteur Institute in Paris.
Genes involved in the body’s first line of defense against pathogens are under strong evolutionary pressure not to change,
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, Quintana-Murci and colleagues report in the

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