Jan. 7 American Journal of Human Genetics,
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. Some of the genes under the strongest pressure are Toll-like receptor genes TLR1, TLR6 and TLR10. Mutations in those genes,
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, which help detect pathogens and coordinate inflammatory responses,
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, could lead to severe, life-threatening diseases, he says.
But there’s a conundrum: In modern humans, these genes would have had to change to deal with new pathogens that humans encountered outside of Africa. It would have taken humans thousands of years to build up the right mutations. Interbreeding with Neandertals may have provided a shortcut to immunity without risking life-threatening mutations,
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, Quintana-Murci surmises. Neandertals had been living with European pathogens for hundreds of thousands of years, gradually accumulating helpful tweaks to ward off the pathogens, but to not overreact and produce strong inflammation that could kill an infected person,
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, he says. Those TLR genes were some of those most often inherited from Neandertals,
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, the researchers found.
“Perhaps spending a night or two with a Neandertal was a small price to pay for getting thousands of years of genetic adaptation,” Capra said at the AAAS press briefing.
Computational biologist Janet Kelso of the Max Planck Institute for Evolutionary Anthropology in Leipzig,
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, Germany, and colleagues also examined the same TLR genes. They report,
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, also in the Jan. 7 American Journal of Human Genetics, that humans had inherited at least

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We are still waiting on the first batch of Jordan Future Low releases, but more colorways are being exposed. We have yet another one that is scheduled to drop mid 2015 known as Black Ice.

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