engineering it and searching for CRISPR-like alternatives,
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, an effort Saey describes in her cover story. Some scientists are going back to the source (bacterial immune systems) to find new enzymes that might help build a library of precision gene-editing tools — one for each job.
That brings me back to why I love microbes — resilient, creative survivors that they are. Like the best humans,
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, they are always coming up with new solutions.

The intricate neural wiring that carries smells to the brain locks into place soon after birth, two new mouse studies suggest. The results,
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, published in the April 11 Science,
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, identify a window of time in which the olfactory system can be scrambled. Once that window closes,
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, the network becomes cemented into the brain,
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, even as newborn neurons continuously stitch themselves into the mix.
“It is a very important finding,” says neuroscientist Leonardo Belluscio of the National Institutes of Health in Bethesda,
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, Md., who was not involved in the studies. Understanding the details of how the brain’s olfactory machinery builds and maintains itself might lead to insights into how other parts of the brain could be repaired after injury, he suggests. ?
Some scientists are interested in using neurons produced from stem cells to patch faulty neural wiring,
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, and the new results might one day make that approach more feasible. Figuring out which signals prevent or allow new cells to navigate through

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