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A last-ditch weapon against drug-resistant bacteria has met its match in Pennsylvania.
A 49-year-old woman has tested positive for a strain of Escherichia coli resistant to the antibiotic colistin,
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, researchers report May 26 in Antimicrobial Agents and Chemotherapy,
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.
It’s the first time in the United States that scientists have found bacteria carrying a gene for colistin resistance known as mrc-1,
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, write study coauthor Patrick McGann of Walter Reed Army Institute of Research in Silver Spring, Md., and colleagues.
But perhaps even more alarming is that the gene rides on a transferable loop of DNA called a plasmid,
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.
“That means we now see a possibility of spread,” says physician and clinical microbiologist Robert Skov. And not just from mother cell to daughter cell, he says,
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, but to neighboring strains of bacteria,
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, too.
Bacteria carry most of their genetic information in a tangle of DNA contained in chromosomes inside the cell. But tiny loops of DNA called plasmids hang around outside of the tangle. These loops carry extra information that bacteria can use, like how to protect themselves from antibiotics. Bacteria can swap plasmids like trading cards,
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, effectively spreading instructions for antibiotic resistance.

Countries with antibiotic-resistant mcr-1 gene in humans as of March 1, 2016


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