lactic acid, ethanol and glucose.
Working with such big datasets can be expensive, too. Compiling the first human genome took 10 years and cost almost $3 billion. Now,
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The important players
Scientists would like to understand the interplay between the genome and the proteome. Add in the metabolome. To make things more complex,
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, there’s the epigenome — the chemical modifications to DNA that help control which genes are turned on and off — and the transcriptome, the full range of RNAs that translate DNA’s blueprints so they can be used to make proteins. It’s no surprise that mapping such a comprehensive network for any organism is still a distant goal.
For now,
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, scientists tend to focus their multi-omic studies on a particular disease or question. Baliga wants to learn how tuberculosis — which sickens nearly 10 million people per year and kills 1.5 million — evades drugs within the body. Many strains of the TB bacterium are resistant to existing treatments or can tolerate them long enough to establish a strong foothold.
To learn how Mycobacterium tuberculosis mounts a defense against a drug,
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He collects different types of omic data from M,
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