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We all come into this world with sealed orders,
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, said 19th century philosopher S?ren Kierkegaard. Although the great Dane lived at a time when much of science was still gauzy and life events were often ascribed to fate,
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, the notion seems to hold true today. A quick scan of newborn babies snoozing in a maternity ward offers little hint of what their futures hold.
But medical researchers are now unsealing these orders by seizing on a simple clue?—?a newborn’s weight. Having established that being too small at birth carries health risks down the road, researchers are also finding that high birthweight comes with baggage.

A protein that can switch shapes and accumulate inside brain cells helps fruit flies form and retrieve memories,
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, a new study finds.
Such shape-shifting is the hallmark move of prions — proteins that can alternate between two forms and aggregate under certain conditions. In fruit flies’ brain cells,
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, clumps of the prionlike protein called Orb2 stores long-lasting memories,
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, report scientists from the Stowers Institute for Medical Research in Kansas City,
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, Mo. Figuring out how the brain forms and calls up memories may ultimately help scientists devise ways to restore that process in people with diseases such as Alzheimer’s.
The new finding,
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