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new study suggests that a metabolite of ketamine — not the drug itself — fights depression. Inside the body, ketamine gets converted into a slew of related molecules. One of these breakdown molecules, a chemical called (2R,6R)-hydroxynorketamine, cheap jordan shoes , is behind the benefits, http://cheapjordansstock.com , neuropharmacologist Todd Gould of the University of Maryland School of Medicine in Baltimore and colleagues found. On its own, cheap real jordans , a single dose of (2R,6R)-HNK reduced signs of depression in mice, restoring their drive to search for a hidden platform in water, to try to escape a shock and to choose sweet water over plain. A type of ketamine that couldn’t be broken down easily into HNKs didn’t ease signs of depression in mice. Finding that a breakdown product, cheap retro jordans , and not ketamine itself, cheap air jordans , was behind the results was a big surprise, Gould says. That surprise could turn out to be valuable. Ketamine comes with serious side effects for people — hallucinations, floating sensations and clumsiness, for example. And at high enough doses, the drug is an anesthetic. But (2R,6R)-HNK may avoid these problems, cheap Authentic jordans , experiments on mice movement indicate. “It’s actually pretty amazing how high a dose we went up to and didn’t see any ill effects,” Gould says. And since ketamine has already been used to treat depression, cheap jordans free shipping , he says, the breakdown product has been inside people with no apparent ill effects. Gould says that the behavioral improvements and lack of side effects make him optimistic that (2R, cheap wholesale jordans ,6R)-HNK can be developed into a safe and effective antidepressant. He and his colleagues plan to test the ketamine http://www.magicadams.com/guest.php/ardguest.php http://www.siempreluce...p;view=article&id=115 http://www.regards-publicite.com/ |