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21.01.2017, 09:07 - nieeshoes - Rank 6 - 1159 Posts
and cell growth and survival. When starvation sets in, cells turn off mTOR’s activity, which allows a self-cannibalizing process called autophagy to scavenge nutrients by digesting some of the cell’s internal organs. This internal garbage disposal and recycling method also removes old,
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, worn-out mitochondria and proteins that may otherwise keep cells from functioning efficiently. That process and other cellular activities governed by mTOR may be responsible for making cells,
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, and organisms,
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, live longer.
Story continues below graphs

Life extension elixir?


Male mice receiving the diabetes drug metformin (top,
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, yellow) had median life spans (the age at which half the population has died) that were slightly longer (8 percent) than untreated male mice (top,
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, gray). Metformin did not increase life spans of female mice. Combined with rapamycin, metformin (teal) boosted median life span in both sexes about 23 percent,
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, but the result wasn’t statistically different from life span boosts in mice given rapamycin alone in previous studies.?

/sites/default/files/2016/07/072316_tina_rapamycin-graph-730_free.png

Source: R,
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. Strong et al/Aging Cell 2016


Rapamycin gave mTOR its name — mechanistic target of rapamycin,
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. Giving the drug might do what caloric restriction

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