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15.02.2017, 05:07 - nieeshoes - Rank 6 - 1159 Posts
Dario DiFrancesco at the University of Milan in Italy,
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, funny channels are key pacemakers that help to determine heart rate. “It is now widely accepted that the HCN4 channel is a marker of pacemaker tissue and controls pacemaking and cardiac rate in a variety of conditions,
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,” DiFrancesco explains. “Whenever changes of cardiac rate are involved,
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, it is natural to think that HCN4 channels may be involved.”
The results, published May 13 in Nature Communications,
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, show that endurance training remodels the heart and reduces resting heart rate by altering the number of funny channels. In the rodents, these changes reversed when the animals were allowed to fall off the exercise wagon.
The findings suggest that “the sinus node has an intrinsic ability to react against the chronically increased heart rate” associated with endurance training, says cardiac physiologist Elizabetta Cerbai of the University of Florence,
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, Italy. The study, she says,
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, has uncovered one of the ways in which the changeable heart can modify itself. Cerbai also notes that long-term sinus node sickness is not limited to athletes. The mechanisms uncovered in this study could also benefit the studies of other heart problems such as heart failure.
Matteo Mangoni, a molecular physiologist at the University of Montpellier in France, found the study to be innovative,
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, and is curious to see what would happen with even longer training regimens. While the rodents did undergo some impressive endurance training,
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, it couldn’t equal the years and years of training that most endurance athletes put

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