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18.02.2017, 08:15 - nieeshoes - Rank 6 - 1159 Posts
But news accounts mostly ignored the flip side of the experiment: Being tethered to an old mouse made young mice age faster. One substance in the blood of old mice,
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, a protein called Beta?2?microglobulin, or B2M, seemed to prematurely age the young ones,
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, Villeda and colleagues reported last year in Nature Medicine (SN: 8/8/15, p. 10). Parabiosis experiments don’t last very long,
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, so no one knows whether youth or decrepitude will win in the end?—?or if the two mice would have settled into middle age together.
UCLA’s Horvath has evidence that the mice may never totally sync. He monitors aging by examining molecular tags called methyl groups,
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, which attach to various locations on DNA in a process called methylation. Methylation is an epigenetic modification of DNA. Such modifications work something like flagging passages in a book with sticky notes. Attaching a tag doesn’t change the information in the book — it just draws attention to some passages and signals that others should be ignored.
Horvath measures DNA methylation changes at 353 different spots in the human genetic instruction book, or genome. As people age,
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, 193 locations accumulate tags, like playbills plastered on urban buildings. At 160 others,
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, methylation is gradually stripped away with age. Knowing how much methylation is normally found at each spot at a given chronological age allows Horvath to calculate biological age,
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.
Taking their time


Semi-supercentenarians (people who live to be 105 to 109, yellow) tend to be biologically younger than their chronological age. So do their children (teal) compared with other people (gray). The rate of aging of the semi-supercentenarians and their children (teal line) is slower than normal (black line).

/sites/default/files/2016/07/072316_tina_methylation-graph_free.png

Source: S,
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. Horvath et al/Aging 2015


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22.02.2017, 11:27 - nieeshoes - Rank 6 - 1159 Posts
If you had to have a prosthetic hand,
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, would you want it to look like a real hand? Or would you prefer a gleaming metallic number, something that doesn’t even try to look human?
A new study looks at one of the issues that prosthetic designers and wearers face in making this decision: the creepy factor. People tend to get creeped out by robots or prosthetic devicesthat look almost, but not quite,
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, human. So Ellen Poliakoff and colleagues at the University of Manchester in England had people rate the eeriness of various prosthetic hands.
Forty-three volunteers looked at photographs of prosthetic and real hands. They rated both how humanlike (realistic) the hands were and how eerie they were, defined as “mysterious, strange,
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, or unexpected as to send a chill up the spine.” Real human hands were rated both the most humanlike and the least eerie (a good thing for humans). Metal hands that were clearly mechanical were rated the least humanlike,
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, but less eerie overall than prosthetic hands made to look like real hands,
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, the team reports in the latest issue of Perception,
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.
[img]/sites/default/files/images/gt_chart_eerie[/img]The realistic prosthetics,
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, like the rubber hand shown above,
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, fell into

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