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08.03.2017, 11:43 - nieeshoes - Rank 6 - 1159 Posts
specific times,
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, in specific places,
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, in response to specific environmental pressures.

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Connections between genes and their outputs (top,
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, left) or within omic layers (bottom,
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, left) can provide some clues to what’s happening inside an organism. But integrating omic datasets can reveal a much more complete view of biological activity (right).

/sites/default/files/2016/10/102916_omics-layered-diagram.png

Source: Katsuyuki Yugi et al/Trends in Biotech,
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. 2016


While the genome remains mostly stable over time,
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, other “omes” change based on what genes are turned on and off at particular moments in particular places in the body. The proteome (all an organism’s proteins) and the metabolome (all the metabolites, or small molecules that are the outputs of biological processes) are two of several powerful datasets that become more informative when used together in a multi-omic approach. They show how that genomic instruction manual is actually being applied.
“The genome tells you what can happen,” says Oliver Fiehn,
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, a biochemist at the University of California,
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, Davis. The proteome and the metabolome can show what’s actually going on.
And just as city planners use data about traffic patterns to figure out where to widen roads and how to time stoplights, biologists can use

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