MIXED SIGNALS Minibrains grown in the lab form nerve cells (red) prematurely and show signs of dying cells (green) when treated with a signaling molecule called LIF. This molecule pours out of embryonic cranial cells after infection with Zika virus, and could harm brain development.







Rachel Greenberg




Zika virus can infiltrate the cells that give rise to bone, cartilage and muscles in the head, researchers report September 29 in Cell Host & Microbe,

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.



In utero infection of these cells, called cranial neural crest cells, could improperly mold babies’ facial features, the authors suggest. The findings — so far observed only in cells and minibrains grown in the lab — offer a possible explanation for the misshapen heads that are the hallmark of microcephaly, a condition that afflicts some babies infected with Zika.

Another hitch: The virus made cranial cells unleash a flood of molecules that can alter brain cell development. So in addition to disfiguring the skull, infected cranial cells might also disrupt the brain,
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, the researchers propose.

Thu, 29 Sep 2016 15:40:46 +0000 https://www.sciencenew...s-can-pass-zika-offspring



Science Ticker






5:00pm, August 29, 2016

























INHERIT THE VIRUS Lab tests show that Aedes aegypti mosquitoes don’t need to bite someone to pick up Zika virus; youngsters (larvae shown) can inherit the virus from their moms.







Dr. Pratt/CDC




Female mosquitoes carrying the Zika virus can pass the infection to the next generation,

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, lab tests show.



Among Aedes aegypti mosquitoes,
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, thought to be the main species spreading Zika in the Americas, at least one out of every 290 lab offspring catches the virus from its mother, Texas researchers say August 29 in the Journal of Tropical Medicine and Hygiene. Infected eggs, which can survive for months on dry surfaces,
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, could keep the virus circulating even after dry or cold spells, when adult mosquitoes die off, warns Robert Tesh of University of Texas Medical Branch in Galveston.

Earlier research had already shown that youngsters of this species can inherit related viruses, such as those causing dengue,
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, West Nile and yellow fever. Mom-to-egg transmission though is not a given: The same research project also reported no evidence so far of this vertical transmission in 803 offspring of another possible Zika spreader, Ae. albopictus.

It’s not known how likely mosquito moms are to infect their young outside of the lab. Doing a reliable test with wild mosquitoes outdoors is a much more difficult project,

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, the researchers say.



Mon, 29 Aug 2016 20:24:37 +0000 https://www.sciencenew...ls-brain-cells-adult-mice



News in Brief





Health,


Neuroscience,





Zika virus





Virus’s effects could be more far-reaching than thought, finding suggests







By





Meghan Rosen







12:00pm, August 18,
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, 2016

















VIRAL TARGET In adult mice, Zika virus infects cells (green) in a region of the brain involved in memory and learning.







H. Li et al/Cell Stem Cell 2016





Citations




H. Li et al. Zika virus infects neu... and alters proliferation. Cell Stem Cell. Published online August 18, 2016. doi:10.1016/j.stem.2016.08.005.





Further Reading




M. Rosen. Mouse studies link Zik...infection to microcephaly,


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.
Science News. Vol. 189, June 11,
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, 2016, p. 15.

&nbsp,
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;


L. Sanders and M,
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. Rosen. Scientists probe Zika’... to neurological disorder. Science News. Vol. 189, April 2, 2016, p. 29.




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