Ketamine,
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, a drug that has shown promise in quickly easing depression, doesn’t actually do the job itself. Instead,
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, depression relief comes from one of the drug’s breakdown products,
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, a new study in mice suggests. The results, published May 4 in Nature, identify a potential depression-fighting drug that works quickly but without ketamine’s serious side effects or potential for abuse.
The discovery “could be a major turning point,
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,” says neuroscientist Roberto Malinow of the University of California, San Diego. “I’m sure that drug companies will look at this very closely.”
Depression is a pernicious problem with few good treatments. Traditional antidepressants don’t work for everyone,
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, and when the drugs do work,
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, they can take weeks to kick in. Ketamine, developed in the 1960s as a sedative for people and now used commonly by veterinarians to knock out animals, can ease depression in minutes, not weeks,
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, small studies show.

Chemical scene


A ketamine metabolite called (2R,6R)-HNK (chemical structure shown) may exert antidepressant effects, a new study suggests.



Source: P. Zanos et al/Nature 2016,
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