. Attaching a tag doesn’t change the information in the book — it just draws attention to some passages and signals that others should be ignored.
Horvath measures DNA methylation changes at 353 different spots in the human genetic instruction book, or genome. As people age,
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, 193 locations accumulate tags,
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, like playbills plastered on urban buildings. At 160 others,
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, methylation is gradually stripped away with age. Knowing how much methylation is normally found at each spot at a given chronological age allows Horvath to calculate biological age.

Taking their time


Semi-supercentenarians (people who live to be 105 to 109,
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, yellow) tend to be biologically younger than their chronological age. So do their children (teal) compared with other people (gray). The rate of aging of the semi-supercentenarians and their children (teal line) is slower than normal (black line).?



Source: S,
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. Horvath et al/Aging 2015


Some people age at different rates than others,
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, he discovered. For instance, semi-supercentenarians — people who live to be 105 to 109 — are about 8.6 years younger epigenetically than their chronological age. Their children are slow to age,
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, too,
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, though not as slow as their parents. Epigenetic clocks indicate that the offspring

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