are about five years younger biologically than other people of the same chronological age,
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.
People often joke about certain abilities,
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, memory or hearing being “the first to go.” Some of Horvath’s work suggests that the notion isn’t entirely far-fetched. He calculated the epigenetic age of specific organs and discovered that body parts can age at different rates. The cerebellum, the part of the brain that sits at the top of the brain stem and helps coordinate movement, speech and other activities, ages the slowest of the brain regions that Horvath analyzed. While there are natural differences in organ aging, some conditions, such as HIV infection and obesity, can prematurely age certain organs, Horvath and colleagues have found.
These experiments demonstrate that aging and its effects are malleable. “Aging is really plastic — it’s not set in stone,
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,” says Conboy. Consequently,
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, she and other researchers agree,
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, something can be done to slow aging,
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, or perhaps turn it around entirely. But exactly what can be done is vigorously disputed.
Interpret with caution
Most scientists working on aging urge caution in extrapolating promising results in animal studies to humans. For instance, one of the most promising early candidates for a rejuvenation factor from young blood was a protein called GDF11. Reports in 2013 and 2014 concluded that GDF11 levels in blood decline with age; restoring the protein in old animals could reverse some heart problems,
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, improve muscle strength and spur nerve cell growth in the brain. ?Since those reports,

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