Though there was no smoking gun — no single piece of evidence that clinched Zika as the culprit — little clues began adding up,
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, beginning with the conspicuous timing of Brazil’s microcephaly upsurge (SN: 4/2/16, p. 26). In January the CDC first issued a warning to pregnant women to postpone travel to Zika-affected regions. On April 13, a day that may be forever etched into Rasmussen’s memory, she and colleagues reported “a causal relationship...een Zika and microcephaly,
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, along with other birth defects, in a study published online in the New England Journal of Medicine. Since then, Rasmussen says, “The data have become absolutely overwhelming.”



This is the year that people became convinced that this mosquito-borne virus could cause birth defects.


— Sonja Rasmussen

In May,
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, a mouse study offered the first direct proof in animals that in utero Zika infection can lead to microcephaly (SN Online: 5/11/16). In September,
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, researchers reported that a pregnant pigtailed macaque infected with Zika in the third trimester then gave birth to a baby whose brain had stopped growing. In human babies,
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, the range of disorders linked to Zika has ballooned to include problems with the eyes,
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, ears and joints, as well as seizures and extreme irritability (SN: 10/29/16, p. 14). At a workshop in North Bethesda, Md.,
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, this fall, a room crowded with doctors and scientists watched videos of inconsolable infants jerking erratically,
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, arms and legs unnaturally stiff. “Heartbreaking,” Rasmussen says.

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