The issue is an urgent one,
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. The globe’s population has never been older,
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. According to the U,
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.S. Census Bureau’s 2015 An Aging World report, by 2020 the number of people 65 and older worldwide will outnumber children 5 and under for the first time in history. Seniors will make up 22.1 percent of the U.S. population in 2050, and nearly 17 percent globally (a whopping 1.6 billion people),
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, the demographers predict. Worldwide, the 80-and-above crowd will grow from 126 million to 447 million. It’s a population sea change that will have ripple effects on culture, economics, medicine and society.
Scientists working at the frontiers of the field do agree that there are probably many ways to slow aging, Tina Hesman Saey reports in this special issue. Saey sums up current thinking on the actors of aging, as well as a number of intriguing approaches ...well tame aging’s effects. The goal,
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, most agree,
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, is not to find a fountain of youth but the keys to prolonging health.
It turns out that healthy aging in people does occur naturally. It is, however, in the words of Ali Torkamani,
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, “an extremely rare phenotype.” Torkamani leads a genetic study of people 80 and older who are living free of chronic disease, described by Saey in her story. He and his team failed to find a single set of genes that protect these “wellderly.” Instead, the people studied carry a plethora of different genetic variants. They do share a lower risk of heart disease and Alzheimer’s. And, he says, the data hint that gene variants linked to key cognitive areas may be at play,
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, leading him to ask: “Is cognitive health just one of the components of healthy aging? Or is there something about having a healthy brain that protects against other signs of aging?”

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