One way to keep stem cells and other cells working is to avoid the loss of telomeres capping the ends of chromosomes. As cells divide,
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, their telomeres grow shorter until they are so short that chromosomes can no longer safely replicate. That may be a signal for the cell to shut down or die. So some researchers think that lengthening telomeres could give cells the protection needed to survive longer.
One biotechnology company executive flew from the United States to Colombia to try out her company’s gene therapy for lengthening telomeres. That decision bypassed U.S. government and other safety measures designed to protect human study participants. And no one knows whether it will work or doom her to cancer,
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, which often relies on long telomeres to keep growing.
Other researchers are exploring more measured approaches to antiaging therapies. One study in dogs is testing rapamycin,
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, the first drug shown to lengthen mouse life spans. Rapamycin is an immune suppressant that also has anticancer effects. The rationale for using it came from research on caloric restriction,
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, the world-champion method for making animals live longer. Animals on calorie-restricted diets typically eat at least 25 percent fewer calories than normal. Such low-cal treatment has increased life spans in mice, dogs, fruit flies,
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, yeast, worms and other lab organisms. Results from primate studies have been mixed (SN: 8/1/09, p. 9,
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; SN: 10/6/12, p. 8),
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. Some people have put themselves on caloric-restriction regimes (SN: 10/25/08, p. 17). A handful of studies suggest that those people have better health,
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, but it’s too soon to know whether they will outlive their peers.

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