This artificial joining of two separate animals,
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, known as parabiosis, was a staple of physiology experiments for over a century before Irina Conboy got the idea to pair an old mouse with a young one. Conboy,
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, a stem cell researcher at the University of California,
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, Berkeley,
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, made headlines with her experiments.
Story continues below graphs
Odd couples


Scientists sewed together mice so that the rodents shared blood supplies. Young mice paired with old mice (left chart,
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, two-toned) made fewer new cells in the brain’s hippocampus than when paired with another young mouse (yellow). Old mice made hundreds more new brain cells when paired with a young mouse (right chart,
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, two-toned) than when paired with an old mouse (teal).



Source: S. Villeda et al/Nature 2011

Those headlines focused on the good news: Young blood rejuvenated old mice. In further studies by other researchers,
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, infusions of young blood made broken bones in old mice heal better (SN Online: 5/19/15),
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, gave their muscles extra spring and improved their memories (SN: 5/31/14, p. 8). Apparently some substances in the blood triggered the rejuvenation. Some candidates for those rejuvenation factors have been identified, although none are universally agreed on.

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