That lockdown is for the greater good, says aging researcher Judith Campisi,
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, who studies senescence at the Buck Institute for Research on Aging in Novato, Calif. “It’s protective,
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,” she says. “You don’t want defective cells to propagate.” (When damaged cells continue to grow they may become cancerous.)
Unfortunately,
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, says Campisi,
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, the senescent cells don’t die. Instead they send out messages to neighboring cells: “Hey, there’s a problem. Be prepared. What happened to me could happen to you.” Such messages are probably intended as public service announcements, but they could trigger mass panic and inflammation. Like zombies putting the bite on the living,
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, senescent cells damage surrounding cells and accelerate aging.
Researchers have worked out methods for hitting the zombie cells with genetic shots to the head, effectively destroying the cells and removing them from the body. Mice from which senescent cells have been removed had increased median life span and improved health, researchers reported in Nature in February (SN: 3/5/16, p. 8).
Campisi and other researchers are working on ways to clear senescent cells from humans,
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, too. But no antiaging treatment makes mice or any other animal live forever. Researchers have yet to increase a mouse’s life span (which rarely goes above two years) to five years,
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, although one mouse fell just short of that mark.
Much research suggests that things that extend life span,
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, such as rapamycin, might not stretch health spans. Mutations that make millimeter-long transparent worms known as Caenorhabditis elegans live longer also extend the proportion ...e worms spend being frail, Heidi Tissenbaum of the University of Massachusetts Medical School in Worcester and colleagues reported last year in the Proceedings of the National Academy of Sciences.

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