But studies of mice suggest that disclaimer may not be necessary. Research by Miller and others suggests that metformin may not prolong life. They have been dosing mice with various chemicals, including metformin and rapamycin,
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, looking for drugs that will make mice healthier and live longer. In a new study, published online June 16 in Aging Cell,
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, Miller and colleagues fed mice metformin starting when the rodents were 9 months old — middle age for a mouse. Combining metformin and rapamycin didn’t make the mice live much longer than rapamycin alone did in previous trials.
Cellular zombies
Other researchers are hoping to stave off death by getting rid of the undead. Cellular zombies called senescent cells are stressed cells that have entered a type of stasis — they’re not dead,
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, but they’re not functioning either. Stress for cells usually means severe DNA damage that could produce cancer, critically short telomeres or other molecular catastrophes that trigger shutdown mode.
Live longer,
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, but frailer


Mutations in certain genes (daf-2,
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, ife-2,
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, eat-2 and clk-1) can make Caenorhabditis elegans worms live longer than normal worms without these mutations. But researchers examining health measures,
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, such as the worms’ ability to move or to withstand heat or oxidative stress, found that long-lived mutant worms spend a smaller proportion of their lives as healthy animals (indicated in yellow).



Source: A,
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. Bansal et al/PNAS 2015


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