whole country may grind to a halt for a few weeks,” says Tom Solomon,
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, a neurologist at England’s University of Liverpool who has studied enterovirus 71 in Malaysia. “Vaccination is a major step forward,” he says.
The two experimental vaccines tested use slightly different inactivated forms of enterovirus 71. Both trigger the immune system to build an army of antibodies against the real pathogen.
In one trial,
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, 12,000 children between 6 months and 6 years of age received either two shots of the vaccine four weeks apart or two placebo shots. The vaccine was highly effective. While 151 children who got the placebo shots developed illness caused by enterovirus 71 over the next 11 months, only four in the vaccinated group came down with it. The follow-up spanned two peak epidemic seasons in China.
In the other study,
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, 10,007 children who were 6 months to 3 years old similarly received placebo or vaccination shots. Over a year,
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, that vaccine also showed strong protection: 106 of the children who got the placebo, but only 13 of the vaccinated kids,
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, developed disease from enterovirus 71.
The second research team also tracked severe illness and found that 24 children in the placebo group ended up in the hospital while none of the vaccinated children did.
“Our study indicates that infants and young children can be protected against enterovirus 71–associated hand, foot and mouth disease,
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,” says Nan Wang,
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, a coauthor of the study of 10,007 children. She is a vaccine researcher and vice president at Sinovac Biotech in Beijing,
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, which makes the vaccine

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