more than 28,000 people of European descent to determine whether genes from extinct ancestors were associated with diseases. Genetic variants inherited from Neandertals were associated with a slightly increased ris...pression and heart attack?as well as corns and callouses and other skin disorders,
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, the researchers reported February 11 at the American Association for the Advancement of Science’s annual meeting in Washington, D.C.,
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, and in the Feb. 12 Science.
For instance,
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, Neandertal variants account for about 1 percent of the genetic risk of getting depression. Interestingly,
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, some bits of Neandertal DNA actually seem to protect against depression,
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, study coauthor Corinne Simonti,
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, also of Vanderbilt University, said at a press briefing at the AAAS meeting. So whether a person is depressed may depend, in part,
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, on which bits of Neandertal DNA they inherited.
Other researchers caution that Capra’s group hasn’t demonstrated that the Neandertal variants are the genetic changes responsible for the disease. They may be innocent bystanders implicated just by their proximity to variants that are really causing problems. And,
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, says evolutionary geneticist Rasmus Nielsen of the University of California, Berkeley, “because we’re talking about genetic variation here, the effect is not in one direction — so the study doesn’t show that you’re more (or less) likely to become ill because of Neandertal DNA.”
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