drops. To up their activity, they‘d need to increase their flexibility. That could make them less stable at higher temperatures — more likely to lose their shape and stop working. But now, it seems that some enzymes can have the best of both worlds.
The idea of a generalist enzyme that works well across a wide temperature range isn’t new — scientists have engineered such proteins in the lab,
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, Shamoo says. But this work shows it might have happened in a real-world setting. “Just because I can do something in the laboratory,
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, that I can build an enzyme that’s a true generalist, doesn’t mean that’s how it happened on this planet,” he says.

As reported this week,
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, breathing elevated ozone levels can mess with the cardiovascular system, potentially putting vulnerable populations — such as the elderly and persons with diabetes or heart disease — at heightened risk of heart attack,
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, stroke and sudden death from arrhythmias. Is this really new?

Turns out it is,
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, says Robert Devlin, the Environmental Protection Agency toxicologist who led the new study,
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. Among the chief priority air pollutants affecting human health that his agency regulates are ozone and near-nano-scale particles called PM (for particulate matter). Although air pollution can affect the heart,
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, there has been a longstanding question about which constituents deserve the blame.

In urban areas especially,
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, many different pollutants

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