11,
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.
This preference is yet another one of Zika’s peculiarities. Two other mosquito-borne diseases,
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, dengue and chikungunya,
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, don’t seem to discriminate between men and women. In previous years in Puerto Rico, cases of these diseases were split evenly.
Researchers are still grappling with how to explain the disparity. Zika and all of its mysteries could be on scientists’ radar for the long term. Though infections may soon wind down within the continental United States,
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, case counts are still ticking upwards in some places. Puerto Rico has reported more than 33,000 confirmed cases and Florida is up to 1,
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,169 cases as of November 16.?
This week, scientists picked up a clue to the gender bias mystery,
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, and learned more about how Zika may be transmitted — and how to clean it up.
Zika thwarts vaginal tissue’s defenses
The vaginal immune systems of mice don’t get riled up for Zika virus, Shazada Khan and colleagues report November 16 in the Journal of Experimental Medicine.
Mice infected with Zika in the vagina had a sluggish immune response and didn’t immediately release the virus-fighting molecules that would usually combat Zika. The same was true of another RNA-based virus called LCMV, the researchers found.
For these viruses,
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, “vaginal tissue is exceptionally vulnerable to infection,” writes Khan,
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, of the Gladstone Institutes in San Francisco. It’s a possible molecular answer for why women may be at a greater risk for Zika than men.
Mosquito

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