.nl/research/news/2014/03/3d-printed-skull-implanted-in-patient.htm">Dutch hospital announced that it had removed the entire top of a woman’s skull and replaced it with a plastic implant,
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, custom-made using a 3-D printer. The story, with a video (below) and amazing photos of the 22-year-old woman’s delicate pink brain encased in a thin piece of clear plastic,
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, went viral immediately.
But what I wanted to know, and couldn’t find in any of the reports, was what condition could make a person’s skull grow 5 centimeters (2 inches) thick, which made the surgery necessary.
There are several bone-thickening diseases that were possible contenders,
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, sparking some initial speculation among science writers on Twitter: Could it be melorheostosis? Osteopetrosis,
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, fibrous dysplasia?
But this one would be a stumper for anyone but Dr. Gregory House,
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, or a Dutch geneticist. So I asked the hospital where the surgery was performed,
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, UMC Utrecht in the Netherlands, and learned that the woman has van Buchem disease,
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, a rare condition found almost entirely among small pockets of closely related Dutch people. The disease, formally called hyperstosis coricalis generalisata,
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, was first described in 1955 by Dutch physician Frans van Buchem. Patients had thickened skulls and jaws, giving them

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