a distinctive appearance,
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, as well as thicker ribs and long bones. It was soon clear that the condition was passed down in families. Thirteen more cases turned up in the 1960s and ’70s,
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, all in people living in a small Dutch village. In 2013,
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, researchers were able to find 18 Dutch people with the condition,
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.
[img]/sites/default/files/images/skull2_3-from[/img]The thickening of the skull and jaw can be extreme. “The weight of the skull and mandible is grossly increased,
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, in some patients to more than three times the normal weight,
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,” researchers reported?in 1998. People with the condition rarely break bones,
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, including one case in which a patient emerged fracture-free after crashing a motorcycle into a tree at “very high speed.” The condition also makes it hard to stay afloat in water,
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, so patients report having to swim continuously to avoid sinking.
We now know that van Buchem disease is caused by a genetic mutation

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