GOING GLOBAL ?An antibiotic-resistant gene, mrc-1, had cropped up in a number of countries across the globe by March 1, 2016. Now, scientists have found E. coli bacteria carrying the gene in the United States, too.?

R.L. Skov and D,
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.L,
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. Monnet/
Eurosurveillance 2016



In December, Skov and colleagues discovered a Danish patient carrying bacteria with mcr-1 plasmid DNA, like the woman in Pennsylvania. And in November of 2015,
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, researchers reported something similar in China.
Until then,
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, all known colistin resistance was due to tweaks in chromosomal DNA (which,
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, unlike plasmid DNA, isn’t easily spread among bacteria), says Skov,
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, of the Statens Serum Institut in Copenhagen,
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, who was not involved with the new work.
Colistin, a 50-year-old drug that doctors largely stopped prescribing in the 1970s because of its side effects, has made a comeback in the last five to 10 years. It’s used when other antibiotics fail; it’s a treatment option for people infected with multidrug-resistant bacteria. Now,
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, with colistin-resistant bacteria, Skov says, antibiotic treatment options are becoming more and more limited.
The problem, scientists have been pointing out for years, is that people

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