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nieeshoes
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09.03.2017, 11:43 offline quote 

and develop an armored layer of bacterial cells called a biofilm that is notoriously difficult to defeat. Researchers and doctors have tried a number of physical and chemical methods — including microneedles,
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, heat, sound waves and solvents — for getting past biofilms and the upper layer of skin to the site of deeper infections.
Previous work with ionic liquids showed that some act as antimicrobials,
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, and others can transport drugs through the skin. “It wasn’t obvious that one set of ionic liquids could work against both the barriers,
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,” says study coauthor Samir Mitragotri, a chemical and bioengineer at the University of California, Santa Barbara. The research was published August 25 in the Proceedings of the National Academy of Sciences,
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.
Ionic liquids are made of salts, positively and negatively charged molecules held together by their charge. While the strength of ionic bonds makes most salts — like sodium chloride — solids, the large size of certain molecules lowers the salts’ melting points so they are liquid at room temperature. Ionic liquids are gaining popularity in industries including chemical manufacturing and processing,
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, solar energy and new battery technology.
Mitragotri experimented with a dozen ionic liquids,
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, which he describes as quite viscous,
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, like honey. His group tested how well the liquids killed two different bacterial biofilms,
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, their ability to enhance drug penetration through the skin and whether they cause unwanted damage to skin cells.
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