In a multivirus competition, a newcomer came out on top for its ability to transport genetic cargo to a mouse’s brain cells. The engineered virus AAV-PHP.B was best at delivering a gene that instructed Purkinje cells, the dots in the micrograph above, to take on a whitish glow. Unaffected surrounding cells in the mouse cerebellum look blue. Cargo carried by viruses like AAV-PHP.B could one day replace faulty genes in the brains of people.
Similar competitions could uncover viruses with the ability to deliver genes to specific types of cells, the researchers write. Selective viruses that can also get into the brain would enable deeper studies of the brain and might improve gene therapy techniques in people.?
AAV-PHP.B beat out other viruses including a similar one called AAV9, which is already used to get genes into the brains of mice. Genes delivered by AAV-PHP.B also showed up in the spinal cord, retina and elsewhere in the body, Benjamin Deverman of Caltech and colleagues report in the February Nature Biotechnology.
Black holes take light for a spin Newly discovered effect could aid observations of Milky Way's monster By Ron Cowen , 17:41 PM February 11, 2011 Given how weird black holes are, it’s only fitting that researchers have found a screwy way to detect the rotation of these gravitational monsters. Existing telescopes could be equipped with special detectors to record the twist imprinted on light waves that pass near a rapidly spinning black hole, Bo Thidé of the Swedish Institute of Space Physics in Uppsala and his colleagues report online February 13 in Nature Physics . The newly discovered effect that spinning black holes have on light wav... Source URL:
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