Thousands of women at risk of breast and ovarian cancer could be spared surgery after researchers found that a common osteoporosis drug may prevent the diseases.
The breakthrough, which scientists are hailing as a potential ‘Holy grail’ in
cancer prevention, will help women born with mutations in their BRCA1 gene.
BRCA1 has been dubbed the ‘Jolie Gene’ after
Angeline Jolie, the actress,
cheap real jordans,http://oforyou.com/jforum/posts/list/0/27077.page#30792cheapjordanshoesfreeshipping.com/bolg, opted for a double mastectomy and hysterectomy to stop cancer on learning that she carried the genetic fault.
Around one?in 1,000 women also carry the mutation which raises their chance of breast cancer from 12.5 per cent to 58 per cent and increases their risk of ovarian cancer 29 fold.
But now Australian scientists have found the cells which cause the disease,
jordan shoes, and a way of prevent them turning cancerous.
The breakthrough came when researchers noticed that the pre-cancerous cells were fuelled by the same protein which drives the bone-destroying cells behind osteoporosis. ?
Crucially,
Kicksokok.com, a drug called denosumab, already exists to shut the protein down. Lab trials on breast tissue from BRCA1 cancer patients showed the medication could prevent tumour formation. Trials in mice also showed a similar result.?
"It is very exciting to think that we may be on the path to the 'Holy grail' of cancer research, devising a way to prevent this type of breast cancer in women at high genetic risk,
cheap jordans,” said Professor Jane Visvader, of the
Walter and Eliza Hall Institute, in Melbourne.
"By thoroughly dissecting how normal breast tissue develops, we have been able to pinpoint the precise cells that are the culprits in cancer formation.”
With great fanfare,
cheap wholesale jordans,http://users.atw.hu/sj/index.php?site=forum_topic&topic=49533cheapjordanshoesfreeshipping.com/bolg, a deal was finally struck on the terms of Britain’s departure from the EU on Friday.
The UK has agreed to cough up a ?39bn divorce settlement,
cheap jordans free shipping, commit to avoiding a hard border on the island of Ireland, and allow European laws to hold sway over EU citizens rights for a further eight years.
But will Britain live up to those promises? David Davis, the Brexit secretary, set off alarm bells in Dublin and Brussels over the weekend after suggesting that the deal was “not legally enforceable.”
He later backtracked on the remark, saying on Monday that the deal was “more than legally enforceable.”
Later that day a spokesman for the European Commission said that the deal was “formally speaking not legally binding.” Instead, the spokesman said, it was a deal “between gentlemen.”
What does that mean?
It raises two burning questions,
cheap jordan shoes. The first is whether the UK now has a legal obligation to meet the commitments laid out in the divorce deal,
cheap retro jordans.
The second question, more prevalent among Eurosceptics, is whether the UK can still walk away from the negotiating table if it becomes clear that a comprehensive trade deal cannot be secured.
Though Theresa May’s cabinet has offered guarded approval of her divorce deal,http://siemprelucenacf.es/index.php/component/user/?option=com_content&view=article&id=115cheapjordanshoesfreeshipping.com/bolg, Michael Gove, the environment secretary, thinks the British public should have the option to reject it at a later date.
Iain Duncan Smith, former leader of the U.K. Conservative Party
Credit: Luke MacGregor
Meanwhile Iain Duncan Smith, the former Tory leader, is “not ecstatic” about the deal. “If they do not demonstrate they are worth negotiating with, or if they try to extract too high a price from us, we can, and should, walk away,” he writes in the Telegraph.
The divorce proceedings might be done, but clearly some in Westminster are pondering whether they can turn back the clock. Here we look at whether this is possible.
Is the divorce deal legally binding?
The short answer is no, but it soon will be. The document widely referred to as the divorce agreement is a report - or a “statement of intent”, as Mr Davis put it. It is not a legally binding treaty.
In other words, the deal struck on Friday has no more legal significance than a handshake, though politically is is hugely significant.
The UK’s promise to accept full regulatory alignment between Northern Ireland and the Republic - failing any other solution to trade and customs issues - was seen as a major step forward by Dublin, for example.
This “handshake” will become legally binding once it is transferred into the Article 50 Withdrawal Agreement, a treaty that will be signed by both sides.
View more!
That treaty can only be drawn up once the EU27 have declared that “sufficient progress” has been made in the talks, which they are expected to do at a European Council summit in Brussels later this week.
“Ultimately, with many uncertainties ahead, this ‘report’ seeks to provide the necessary political commitments necessary for negotiations to move forward and for the existing legal commitments not to be undermined,” said Andrew Hood, a former lead UK-EU negotiator who now works for the specialist law firm Dechert.
But there's a catch. On Monday it emerged that the EU was irritated by Mr Davis' comments about the deal not being legally enforceable. As a result, EU diplomats have tweaked the wording of the resolution that will be put to the European Council.
The resolution now states that trade talks will only begin if the UK's commitments are "respected in full and translated in legal terms as quickly as possible."
This means the wheels of parliament have to start grinding the divorce agreement into domestic legal fodder at the start of next year, adding the key commitments into the UK's Withdrawal Bill.
Once the process is complete and the promises made by the UK have been enshrined in a bill passed by parliament, wriggling out of the deal's current terms will be nigh on impossible. This brings us to question two.
Is 'no deal' is still on the table?
Yes, but it has been significantly watered down. Britain can still withhold the so-called Brexit bill if it is not satisfied with the outcome of the talks on transitional arrangements and trade.
As the prime minister said on Monday in the House of Commons: “Nothing is agreed until everything is agreed...if there is no agreement then our offer also falls away.”
In other words, if a comprehensive free trade deal which lives up to the UK’s demands has not been secured, this element of the “no deal” nuclear option remains on the table.
There is a caveat, however. Though Mrs May intends to follow through on her threat to withhold the bill - if it proves necessary - she will not renege on the Irish border deal.
Leo Varadkar, the Irish prime minister, with Theresa May
Domestic legal issues aside, should the UK abandon this “fail-safe” option, it would not just be viewed as a nation that breaks promises, but one potentially abandoning
the peace process in Northern Ireland.
“If Brexit leaves a hard border, it will be seen as a betrayal in Ireland,” said Anand Menon, Professor of European politics at Kings College London and Director of the UK in a Changing Europe.
“This is an existential issue for the Irish, but it comes as no surprise to them anymore that we don’t get it,” he added, referring to claims that the British government and the public lack a grasp of the details of the Irish border issue.
The British government says it is absolutely committed to avoiding a hard border with the Republic of Ireland, and that it now views a trade deal as the most likely outcome of the negotiations.
Any other options?
Yes. Britain could sweep the entire divorce deal off the table and ask to renegotiate the terms from square one.
This is the most outlandish scenario, however, as the time limit under Article 50 would barely allow it without unanimous approval from the EU27.
At this stage it seems unlikely that Mrs May, or any future prime minister, would want to go through the stress and strain of a divorce process all over again.
