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19.01.2017, 12:52 - anyoshoes - Rank 6 - 1072 Posts
metabolite in clinical trials of people with depression,
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.
A potential concern is that because of ketamine’s ability to warp perceptions, it is sometimes used as a recreational drug of abuse. But the metabolite may not have the same allure. Mice will push a lever to self-administer ketamine, but don’t seem as eager to up their dose of (2R,
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,6R)-HNK,
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, the team found. ?
More experiments are needed to show specifically how (2R,
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,6R)-HNK affects the brain. One of the main explanations for how ketamine itself works is that it blocks NMDA receptors, proteins that sit on particular nerve cells and help strengthen neural connections. But (2R,6R)-HNK has nothing to do with NMDA receptors. If the new results are right, they suggest that NMDA receptors aren’t a good target for an antidepressant drug. “We thought it was one thing but now it seems like it’s something else,” Malinow says.?

Smartphone-toting pilgrims regularly stream into northern Cambodia from all over the world. Their destination: Angkor Wat,
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, a medieval temple that’s famous for massive towers and majestic stone carvings of Hindu gods,
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, spirits and mythological battle scenes. The site,
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, considered the world’s largest religious monument,
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, drew more than 2.3 million visitors in 2014.
Angkor Wat’s sightseers encounter a study in contrasts. This architectural wonder of human civilization ascends skyward, on the verge of being engulfed by nature below. Tourists walk along a path

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